biodistribution study japan

Angiotensin II through binding to its type 1 receptors exerts pro-inflammatory, vasoconstrictive, and prothrombotic effects, while angiotensin (17) has opposing effects In addition, angiotensin II increases cytoplasmic and mitochondrial ROS generation leading to oxidative stress. Their data clearly showed that the injection site retained the largest concentration of these nanoparticles, but the article omitted this fact. Three rats per sex for each group were bled and euthanized on day 1 (~ 4 h post injection), day 2, day 4, day 8 and day 15. (LogOut/ Pfizer also found that the LNP-encapsulated . No published research data on biodistribution of the mRNA vaccines in animals can be found on the internet. The bottom line is mRNA Covid vaccines are still considered experimental by the FDA as research continues to be done. Change). 22 23 24 25 Janssen told The BMJ its covid-19 vaccine leverages the same technology as its Ebola vaccine, which received licensure last June. To do that, you need to become metabolically flexible and optimize your diet. Bridle maintains the Vaccine Adverse Event Reporting System (VAERS) database presents evidence of breastfeeding infants encountering bleeding disorders in the gastrointestinal tract. All of this also suggests that for individuals who are at low risk for COVID-19, children and teens in particular, the risks of these vaccines far outweigh the benefits. Specific alterations make it far more toxic than that found on the virus itself. A biodistribution study was conducted using ddY mice (male, 5 weeks old). doi: 10.1371/journal.pone.0135389. Im very concerned because she is planning on breast feeding & who knows what the vaccine has already done to the baby. For an LNP-mRNA vaccine, DNA vaccine, or recombinant virus vaccine, a biodistribution study with the SARS-CoV-2 vaccine candidate is generally needed. In short, when you get the COVID-19 vaccine, you are being injected with an agent that instructs your body to produce the bioweapon in its own cells. After spending 20 hours of research, I found there are. Careers. Pingback: 13th June MUST SEE VIDEOS & DOCUMENTS: Based Amy. Bernal S, Pelaez I, Alias L, Baena M, De Pablo-Moreno JA, Serrano LJ, Camero MD, Tizzano EF, Berrueco R, Liras A. Int J Mol Sci. It only looked at where the lipid nanoparticles go. If any decision is difficult to make, it is usually because one does not have enough facts. Production and hosting by Elsevier B.V. All authors declare that they have no competing interests. This is about as diabolical as it gets. When the spike protein interacts with the ACE2 receptor, it can disrupt mitochondrial signaling, thereby inducing the production of reactive oxygen species and oxidative stress. The bioanalysis methods appear to be adequate. Generally speaking, there are many different kinds and types of vaccines, all with the same objectivetricking a healthy body into thinking it is under attack by a particular disease so the immune system will learn to create the cells and proteins necessary to swiftly destroy the pathogen if it becomes a threat. Unable to load your collection due to an error, Unable to load your delegates due to an error. It was a pre-clinical biodistribution study. As reported by TrialSite News:7. The site is secure. Consensus treatment plans for induction therapy of newly diagnosed proliferative lupus nephritis in juvenile systemic lupus erythematosus. As The Defender reported June 3, Bridle received a copy of a Japanese biodistribution study which had been kept from the public as a result of a freedom of information request made to the Japanese government for Pfizer data. The take-home message Kendrick delivers is that If you damage the lining of blood vessel walls, blood clots are far more likely to form. Study: Adverse events following COVID-19 virus vaccination in Japanese young population: The first cross-sectional study conducted by a questionnaire survey after the first-time-injection. Why do we need it. Consistent data shows the virus is less severe than influenza in children, strengthening the argument of do kids need the vaccine? Voicing his concern, Bridle asserts: Thats not how this is supposed to work; our kids should not be the guinea pigs. Time-restricted eating will upregulate autophagy, while sauna therapy, which upregulates heat shock proteins, will help refold misfolded proteins and also tag damaged proteins and target them for removal. The pandemic and its consequences are constantly evolving and data that was accurate weeks or even days ago might have changed. in Japan for DNA vaccines and recombinant virus vaccines, or prior to the initiation of a large-scale clinical trial in Japan for LNP-mRNA vaccines. The biodistribution was also studied in rats using radiolabeled LNP and luciferase modRNA (study 185350).. After the protein piece is made, the cell breaks down the instructions and gets rid of them. The radiolabeling data, measuring distribution to blood, plasma and selected tissues, of IM injection of a single dose of 50 g mRNA over a 48-hour period is considered more sensitive than the bioluminescence method and indicate a broader biodistribution pattern than was observed with bioluminescence. Pingback: Vaccine Shedding: The Harm for Those Who Choose NOT to be Vaccinated - The Hollywood Conservative, Pingback: Vaccine Shedding: The Harm For Those Who Choose NOT To Be Vaccinated - TruthMatters.biz, Pingback: Breaking News Round Up Continues As The Old Traditional Rite Mass & Sacraments Become Restricted By Pope Francis | Traditional Catholics Emerge, Pingback: A Secular Perspective on Gods Judgment Anonymous, 7/30/21 | pomegranatesandchains, Pingback: LA School District Mandates COVID Jabs for All Students 12 and Older - Vaccine Effects. Well, back in May 2021, I, along with some international colleagues, looked at a document that Pfizer had submitted to the Japanese health regulatory agency. (a) Number of cell-based therapeutic product in cell formulation and number of cell-based therapeutic product with or without biodistribution study in (b) cell-suspension CTP and (c) tissue or cell-sheet CTP (refer to Supplementary Table1). 2018;7(1):7886. What is the real truth? 2021 The Japanese Society for Regenerative Medicine. -, Gu E., Chen W.Y., Gu J., Burridge P., Wu J.C. Molecular imaging of stem cells: tracking survival, biodistribution, tumorigenicity, and immunogenicity. This not only leads to impaired MAVS [mitochondrial antiviral signaling] response but also aggravates inflammation and cell death.. EMA Reviews Pfizer Covid-19 Vaccine Animal Biodistribution Study Data. This is in contrast to current thinking the mRNA vaccine is quickly broken down at its site of injection in the arm implying no distribution to other organs. The Japanese biodistribution study results are consistent with Pfizer's that was submitted to the European Medicines Agency (EMA) in February 2021. Standard studies designed to assess these risks were not performed in compliance with accepted empirical research standards. Many different unusual, prolonged, or delayed reactions have been reported, and often these are more pronounced after the second shot. Likewise, research within thescientific community also reveals various cardiovascular and heart problems, bleeding, and clotting when studying the disease in humans. A Japanese study on the bio-distribution of Covid-19 products shows that mRNA travels to the ovaries and adrenal glands, suggesting why heartburn, blood clots, and other dangerous side. Read summaries of real world examples of proejcts completed by SGW Designworks. We wont know the final answers to many questions concerning the mRNA vaccines until at least 2022 or perhaps longer. Pfizers data, however, show the mRNA and subsequent spike protein are widely distributed in the body within hours, This is a serious problem, as the spike protein is a toxin shown to cause cardiovascular and neurological damage. Support responsible news and fact-based information today! In 2020, Bridle was awarded a $230,000 government grant for research on COVID vaccine development. Low levels of radioactivity were detected in most tissues, with the greatest levels in plasma observed 1-4 hours post-dose. Very often, the damage is caused by the immune system going on the attack, damaging blood vessel walls, and removing several of the anti-clotting mechanisms. The end result can be lethal, and this chain of events is exactly what these COVID-19 vaccines are setting into motion. Prions are membrane proteins and when they misfold, they form crystals in the cytoplasm resulting in prion disease. Please Donate so that we can continue to bring you important updates concerning the Covid Virus Pandemic. https://www.ema.europa.eu/en/documents/assessment-report/comirnaty-epar-public-assessment-report_en.pdf, *https://www.bmj.com/content/373/bmj.n958/rr-1, https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/mrna.html, History of Discovery of Vitamin D, Use of Vitamin D in Chronic Disease, Origins of Vitamin D Toxicity. Brindle, who stated the importance of sharing this new information openly, recently visited On Point with Alex Pierson and spoke at length on the scary situation facing humanity as the push to vaccinate the global population against SARS-CoV-2 gains momentum. As such, it seemed really risky to instruct the bodys cells to produce the very thing that causes severe problems. You are transferring the vaccine itself, as well as the spike protein, which could result in bleeding and/or blood clots in your child. See the post about the approval for details. Bookshelf Avoid all vegetable oils and processed foods. The mouse study used three female BALB-c mice per group and luciferase protein expression was determined by in vivo bioluminescence readouts using an In Vivo Imaging System (IVIS) following injection of the luciferase substrate luciferine. Disclaimer. So the Japanese medicines regulator had required Pfizer to do a study where they looked at how the vaccine distributed around the body, in this case of a . 3 Bioscience & Engineering Laboratory, FUJIFILM Corp., 577 Ushijima, Kaisei-Machi, Ashigarakami-gun, Kanagawa, Japan. The first section is labeled: SARS-CoV-2 mRNA Vaccine (BNT162, PF-07302048) 2.6.4 Summary of pharmacokinetic study The petition and its supporting documents can be downloaded from the FDA website here: https://www.regulations.gov/docket/FDA-2021-P-0521/document, However, information regarding biodistribution of the Pfizer vaccine in animal studies was referenced by the European Medicine Agencys (EMA) review of Pfizers mRNA vaccine data sent to them by Pfizer. Cardiovascular and heart problems, bleeding, and this chain of events exactly. Male, 5 weeks old ) induction therapy of newly diagnosed proliferative lupus in! Been reported, and this chain of events is exactly what these COVID-19 vaccines are into. 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